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Nutraceuticals and Supplements in Managing Prediabetes and Diabetes

Nutrients
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Giuseppe Derosa, Angela D'Angelo, Fabrizio Angelini, Luca Belli, Arrigo F G Cicero, Roberto Da Ros, Giovanni De Pergola, Giovanni V Gaudio, Alessandro Lupi, Giovanni Sartore, Federico A Vignati, Pamela Maffioli

A systematic review conducted by a team of experts from five scientific societies examined the potential role of nutraceuticals and supplements in managing prediabetes and diabetes. The study, titled Nutraceuticals and Supplements in Management of Prediabetes and Diabetes, investigates how these natural compounds might delay or prevent the progression from prediabetes to diabetes.


Key Findings

  • Nutraceuticals Show Promise: The review highlights several nutraceuticals, including berberine, cinnamon, and omega-3 fatty acids, which may help manage blood sugar levels in individuals with prediabetes.

  • Role of Botanicals: Specific botanicals, such as ascophyllum nodosum and gymnemic acid, were identified for their potential to improve glucose tolerance.

  • Diverse Sources: The study covers a variety of sources, including fucus vesiculosus and olea europaea, emphasizing the diversity of nutraceutical options available.

"The addition of nutraceuticals or supplements can be considered to stop or delay the progression to diabetes mellitus over time," said the researchers.

Why It Matters

Diabetes is a chronic condition affecting millions worldwide, leading to severe complications if left unmanaged. The transition from prediabetes to diabetes is a critical period where intervention can yield significant health benefits. Nutraceuticals, often derived from natural sources like plants and marine life, offer a promising avenue for intervention.

Research Details

The research team conducted a search of randomized controlled trials in databases such as MEDLINE and the Cochrane Register of Controlled Trials. They aimed to compile evidence on the efficacy of various nutraceuticals in managing dysglycemia, characterized by impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).

"The purpose was to compile a systematic review about the use of nutraceuticals for treating diabetes and prediabetes," stated the research team.

Their methodology involved searching for terms like "botanicals," "dysglycemia," and specific nutraceuticals such as alpha-lipoic acid and essential amino acids. This approach ensured that only high-quality studies were included in their review, providing a reliable resource for clinicians and researchers.

Looking Ahead

The implications of this study are significant. By providing an overview of the current evidence, the research informs clinical practice and sets the stage for future studies. There is a need for further randomized controlled trials to confirm these findings and explore the mechanisms through which these nutraceuticals exert their effects.

Moreover, integrating nutraceuticals into treatment plans for prediabetes could enhance the management of this condition, offering patients a natural option to control their blood sugar levels.

"The added value of the paper compared to other reviews is that it was written by experts appointed by five different scientific societies dealing with diabetes, nutrition, and complications," the research team noted.

As the world grapples with rising diabetes rates, this study underscores the importance of exploring all possible avenues for prevention and management. Nutraceuticals may hold the key to turning the tide against diabetes, offering hope to millions at risk worldwide.


With the findings of this study, policymakers, healthcare providers, and patients have a renewed focus on the potential of nutraceuticals. The road ahead promises developments in both scientific understanding and practical application of these natural compounds.

Diabetes